Heavy Loss
Big Loss
noun, verbal noun
おおぞん
損 (そん) Disadvantage, Loss
大損 (おおぞん) Heavy Loss, Big Loss
全損 (ぜんそん) Total Loss
遺失 (いしつ) Loss
喪失 (そうしつ) Loss, Forfeit
The ozone おおぞん layer suffered a Heavy Loss.
Losing the ozone おおぞん layer would be a Heavy Loss for humanity.