One's Lifetime
One's Career
noun
しょうがい
障害 （しょうがい） Disability, Handicap, Obstacle
生涯 （しょうがい） One's Lifetime, One's Career
一代 （いちだい） Lifetime, One Lifetime, Generation, One Generation
一生 （いっしょう） Whole Life, All Through Life, Lifelong
Getting a Disability 障害 at some point during One's Lifetime 生涯 is a very real possibility.
One may never meet that shogun しょう guy がい during One's Lifetime.